Description
What is XYMOGEN 5-MTHF Plus B12?
Xymogen 5-MTHF Plus B12 is a high-potency methylated B-vitamin formula that combines active folate (5-MTHF) and active B12 (methylcobalamin) in a great-tasting, quick-dissolve cherry tablet.* It’s designed to support methylation, homocysteine metabolism, nervous system health, and healthy red blood cell formation, especially for people who want bioactive forms of folate and B12 instead of standard folic acid and cyanocobalamin. This is the 60 quick-dissolve natural cherry tablet size.
What is in XYMOGEN 5-MTHF Plus B12?
Each 1 tablet serving provides a focused, research-level dose of active folate and B12:
Active ingredients (per 1 tablet)
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Folate – 1,000 mcg DFE (250% DV)
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As Quatrefolic® (6S)-5-methyltetrahydrofolic acid, glucosamine salt – the biologically active form of folate (5-MTHF) that increases plasma folate more effectively than folic acid.
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Vitamin B12 – 2,500 mcg (104,167% DV)
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As MecobalActive® methylcobalamin, a highly pure, body-ready form of B12 that does not use harsh solvents in manufacturing.
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Other ingredients
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Xylitol, ascorbyl palmitate, silica, and natural cherry flavor – used to create the pleasant quick-dissolve cherry tablet format.
Free-from profile
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Formulated without wheat, gluten, yeast, soy protein, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, GMOs, artificial colors, artificial sweeteners, or artificial preservatives
Why is Xymogen 5-MTHF Plus B12 different from other folate and B12 products?
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Uses bioactive forms – Quatrefolic® + methylcobalamin
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Quatrefolic® 5-MTHF is the glucosamine salt of the most biologically active folate form, bypassing multiple conversion steps that folic acid requires, and increasing plasma folate more effectively than folic acid.
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Methylcobalamin (MecobalActive®) is a methylated, body-ready B12, supporting methylation and neurologic function without the need to convert from cyanocobalamin.
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Supports methylation and homocysteine without UMFA buildup
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5-MTHF Plus B12 is specifically positioned to support methylation pathways, homocysteine regulation, and cellular proliferation (including red blood cells).
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Using 5-MTHF instead of folic acid helps avoid unmetabolized folic acid (UMFA) accumulation, an issue associated with high folic acid intake in some individuals.
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Ideal for individuals with folate metabolism or MTHFR concerns
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5-MTHF is the preferred supplemental form of folate when conversion of folic acid is limited (e.g., certain MTHFR polymorphisms or medication interactions).
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Delivers folate already in the active 5-MTHF form, helping support serum folate levels without relying on genetic or enzymatic conversion steps.
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Professional-grade, allergen-conscious, quick-dissolve format
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Practitioner-focused formula with clean excipients and restricted distribution through professional channels.*
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Great-tasting, quick-dissolve cherry tablet makes it easier for patients who dislike or cannot swallow capsules, which can improve consistency and compliance.
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How should I take Xymogen 5-MTHF Plus B12?
Always follow the product label and your healthcare professional’s guidance.
Suggested use (label directions):
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Take 1 cherry-flavored tablet daily, or as directed by your healthcare practitioner.
Usage notes you can include on the page:
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The quick-dissolve tablet is designed to melt in the mouth; many people take it in the morning to support daily energy, methylation, and nervous system health.
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Your practitioner may adjust timing based on labs (e.g., folate, B12, homocysteine) and specific goals such as pregnancy support, cardiovascular health, or neurologic support.
Important notes
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Consult your healthcare practitioner before use, especially if:
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You are pregnant, nursing, or planning pregnancy
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You take prescription medications or are receiving cancer treatment
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Do not use if the tamper seal is damaged; keep closed in a cool, dry place out of the reach of children.
What are XYMOGEN products?
Xymogen products are science-backed supplements designed to support your optimal health. Discover how Xymogen products can help you achieve your health goals. Read more about XYMOGEN products.
How can I get started with XYMOGEN 5-MTHF Plus B12?
Are you ready to start feeling better? Starting with Xymogen 5-MTHF Plus B12 is easy. Simply schedule an appointment with Cunningham Clinic, discuss your concerns with your provider and then pick up your nutraceutical grade 5-MTHF.
